erk1 2 inhibitor Search Results


sch772984  (CSNpharm Inc)
90
CSNpharm Inc sch772984
Rolipram restores ERK1/2 signaling to block TGF-β1 stimulated LF fibroblast fibrosis. (A) Different drugs were used to treat fibroblasts stimulated by TGF-β1. WB detects the expression of TGF-β1. a, Rolipram (50 nM) is a PDE4 inhibitor.; b, WAY-262611 (1 μM) is the Wnt/β-catenin pathway activator.; c, LY294002 (1 μM) is an inhibitor of the PI3K pathway; d, <t>SCH772984</t> (1 μM) inhibits ERK1/2 signal transduction. (B) The expression of FN1 and TGF-β1 was up-regulated after exogenous TGF-β1 stimulation. Using Rolipram or SCH772984 blocked this change. (C) Western blot analysis reveals the expression levels of p-ERK1/2 and ERK1/2 in LF fibroblasts treated with TGF-β1 (5 ng/ mL) and Rolipram (50 nM, 24 h). β-tubulin served as an endogenous loading control. * p < 0.05
Sch772984, supplied by CSNpharm Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/erk1+2+inhibitor/pmc08461931-77-14-17?v=CSNpharm+Inc
Average 90 stars, based on 1 article reviews
sch772984 - by Bioz Stars, 2026-08
90/100 stars
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anti-phospho-erk1/2  (Biomol GmbH)
90
Biomol GmbH anti-phospho-erk1/2
Rolipram restores ERK1/2 signaling to block TGF-β1 stimulated LF fibroblast fibrosis. (A) Different drugs were used to treat fibroblasts stimulated by TGF-β1. WB detects the expression of TGF-β1. a, Rolipram (50 nM) is a PDE4 inhibitor.; b, WAY-262611 (1 μM) is the Wnt/β-catenin pathway activator.; c, LY294002 (1 μM) is an inhibitor of the PI3K pathway; d, <t>SCH772984</t> (1 μM) inhibits ERK1/2 signal transduction. (B) The expression of FN1 and TGF-β1 was up-regulated after exogenous TGF-β1 stimulation. Using Rolipram or SCH772984 blocked this change. (C) Western blot analysis reveals the expression levels of p-ERK1/2 and ERK1/2 in LF fibroblasts treated with TGF-β1 (5 ng/ mL) and Rolipram (50 nM, 24 h). β-tubulin served as an endogenous loading control. * p < 0.05
Anti Phospho Erk1/2, supplied by Biomol GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/erk1+2+inhibitor/10__1158_slash_0008___5472__can___06___0268-70-0-9?v=Biomol+GmbH
Average 90 stars, based on 1 article reviews
anti-phospho-erk1/2 - by Bioz Stars, 2026-08
90/100 stars
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selective erk1/2 inhibitor azd0364  (AstraZeneca ltd)
90
AstraZeneca ltd selective erk1/2 inhibitor azd0364
Rolipram restores ERK1/2 signaling to block TGF-β1 stimulated LF fibroblast fibrosis. (A) Different drugs were used to treat fibroblasts stimulated by TGF-β1. WB detects the expression of TGF-β1. a, Rolipram (50 nM) is a PDE4 inhibitor.; b, WAY-262611 (1 μM) is the Wnt/β-catenin pathway activator.; c, LY294002 (1 μM) is an inhibitor of the PI3K pathway; d, <t>SCH772984</t> (1 μM) inhibits ERK1/2 signal transduction. (B) The expression of FN1 and TGF-β1 was up-regulated after exogenous TGF-β1 stimulation. Using Rolipram or SCH772984 blocked this change. (C) Western blot analysis reveals the expression levels of p-ERK1/2 and ERK1/2 in LF fibroblasts treated with TGF-β1 (5 ng/ mL) and Rolipram (50 nM, 24 h). β-tubulin served as an endogenous loading control. * p < 0.05
Selective Erk1/2 Inhibitor Azd0364, supplied by AstraZeneca ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/erk1+2+inhibitor/pmc09136582-193-4-8?v=AstraZeneca+ltd
Average 90 stars, based on 1 article reviews
selective erk1/2 inhibitor azd0364 - by Bioz Stars, 2026-08
90/100 stars
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erk-1/2 inhibitor  (Biopharm GmbH)
90
Biopharm GmbH erk-1/2 inhibitor
Rolipram restores ERK1/2 signaling to block TGF-β1 stimulated LF fibroblast fibrosis. (A) Different drugs were used to treat fibroblasts stimulated by TGF-β1. WB detects the expression of TGF-β1. a, Rolipram (50 nM) is a PDE4 inhibitor.; b, WAY-262611 (1 μM) is the Wnt/β-catenin pathway activator.; c, LY294002 (1 μM) is an inhibitor of the PI3K pathway; d, <t>SCH772984</t> (1 μM) inhibits ERK1/2 signal transduction. (B) The expression of FN1 and TGF-β1 was up-regulated after exogenous TGF-β1 stimulation. Using Rolipram or SCH772984 blocked this change. (C) Western blot analysis reveals the expression levels of p-ERK1/2 and ERK1/2 in LF fibroblasts treated with TGF-β1 (5 ng/ mL) and Rolipram (50 nM, 24 h). β-tubulin served as an endogenous loading control. * p < 0.05
Erk 1/2 Inhibitor, supplied by Biopharm GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/erk1+2+inhibitor/pm25904312-127-5-36?v=Biopharm+GmbH
Average 90 stars, based on 1 article reviews
erk-1/2 inhibitor - by Bioz Stars, 2026-08
90/100 stars
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erk1/2 inhibitor sch-772984  (AbMole Bioscience)
90
AbMole Bioscience erk1/2 inhibitor sch-772984
Rolipram restores ERK1/2 signaling to block TGF-β1 stimulated LF fibroblast fibrosis. (A) Different drugs were used to treat fibroblasts stimulated by TGF-β1. WB detects the expression of TGF-β1. a, Rolipram (50 nM) is a PDE4 inhibitor.; b, WAY-262611 (1 μM) is the Wnt/β-catenin pathway activator.; c, LY294002 (1 μM) is an inhibitor of the PI3K pathway; d, <t>SCH772984</t> (1 μM) inhibits ERK1/2 signal transduction. (B) The expression of FN1 and TGF-β1 was up-regulated after exogenous TGF-β1 stimulation. Using Rolipram or SCH772984 blocked this change. (C) Western blot analysis reveals the expression levels of p-ERK1/2 and ERK1/2 in LF fibroblasts treated with TGF-β1 (5 ng/ mL) and Rolipram (50 nM, 24 h). β-tubulin served as an endogenous loading control. * p < 0.05
Erk1/2 Inhibitor Sch 772984, supplied by AbMole Bioscience, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/erk1+2+inhibitor/pmc05907057-178-51-54?v=AbMole+Bioscience
Average 90 stars, based on 1 article reviews
erk1/2 inhibitor sch-772984 - by Bioz Stars, 2026-08
90/100 stars
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erk 1/2 inhibitor 1 (methylthiouracil, hy112287  (Solarbio Inc)
90
Solarbio Inc erk 1/2 inhibitor 1 (methylthiouracil, hy112287
Rolipram restores ERK1/2 signaling to block TGF-β1 stimulated LF fibroblast fibrosis. (A) Different drugs were used to treat fibroblasts stimulated by TGF-β1. WB detects the expression of TGF-β1. a, Rolipram (50 nM) is a PDE4 inhibitor.; b, WAY-262611 (1 μM) is the Wnt/β-catenin pathway activator.; c, LY294002 (1 μM) is an inhibitor of the PI3K pathway; d, <t>SCH772984</t> (1 μM) inhibits ERK1/2 signal transduction. (B) The expression of FN1 and TGF-β1 was up-regulated after exogenous TGF-β1 stimulation. Using Rolipram or SCH772984 blocked this change. (C) Western blot analysis reveals the expression levels of p-ERK1/2 and ERK1/2 in LF fibroblasts treated with TGF-β1 (5 ng/ mL) and Rolipram (50 nM, 24 h). β-tubulin served as an endogenous loading control. * p < 0.05
Erk 1/2 Inhibitor 1 (Methylthiouracil, Hy112287, supplied by Solarbio Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/erk1+2+inhibitor/pm37023880-48-5-14?v=Solarbio+Inc
Average 90 stars, based on 1 article reviews
erk 1/2 inhibitor 1 (methylthiouracil, hy112287 - by Bioz Stars, 2026-08
90/100 stars
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u0126 (erk1/2 inhibitor)  (U73122 PLC)
90
U73122 PLC u0126 (erk1/2 inhibitor)
Rolipram restores ERK1/2 signaling to block TGF-β1 stimulated LF fibroblast fibrosis. (A) Different drugs were used to treat fibroblasts stimulated by TGF-β1. WB detects the expression of TGF-β1. a, Rolipram (50 nM) is a PDE4 inhibitor.; b, WAY-262611 (1 μM) is the Wnt/β-catenin pathway activator.; c, LY294002 (1 μM) is an inhibitor of the PI3K pathway; d, <t>SCH772984</t> (1 μM) inhibits ERK1/2 signal transduction. (B) The expression of FN1 and TGF-β1 was up-regulated after exogenous TGF-β1 stimulation. Using Rolipram or SCH772984 blocked this change. (C) Western blot analysis reveals the expression levels of p-ERK1/2 and ERK1/2 in LF fibroblasts treated with TGF-β1 (5 ng/ mL) and Rolipram (50 nM, 24 h). β-tubulin served as an endogenous loading control. * p < 0.05
U0126 (Erk1/2 Inhibitor), supplied by U73122 PLC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/erk1+2+inhibitor/pm17654254-88-17-20?v=U73122+PLC
Average 90 stars, based on 1 article reviews
u0126 (erk1/2 inhibitor) - by Bioz Stars, 2026-08
90/100 stars
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erk1-2 inhibitor 3  (TargetMol)
N/A
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erk1-2 inhibitor 7  (TargetMol)
N/A
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erk1-2 inhibitor 2  (TargetMol)
N/A
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erk1/2 inhibitor 7  (Aladdin Scientific Corporation)
N/A
ERK1/2 inhibitor 7 is a potent ERK inhibitor with an IC 50 of 0.94 nM for ERK2 (WO2021110168A1, WX006).Form:Solid
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erk1-2 inhibitor 8  (TargetMol)
N/A
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Image Search Results


Rolipram restores ERK1/2 signaling to block TGF-β1 stimulated LF fibroblast fibrosis. (A) Different drugs were used to treat fibroblasts stimulated by TGF-β1. WB detects the expression of TGF-β1. a, Rolipram (50 nM) is a PDE4 inhibitor.; b, WAY-262611 (1 μM) is the Wnt/β-catenin pathway activator.; c, LY294002 (1 μM) is an inhibitor of the PI3K pathway; d, SCH772984 (1 μM) inhibits ERK1/2 signal transduction. (B) The expression of FN1 and TGF-β1 was up-regulated after exogenous TGF-β1 stimulation. Using Rolipram or SCH772984 blocked this change. (C) Western blot analysis reveals the expression levels of p-ERK1/2 and ERK1/2 in LF fibroblasts treated with TGF-β1 (5 ng/ mL) and Rolipram (50 nM, 24 h). β-tubulin served as an endogenous loading control. * p < 0.05

Journal: BMC Musculoskeletal Disorders

Article Title: Rolipram plays an anti-fibrotic effect in ligamentum flavum fibroblasts by inhibiting the activation of ERK1/2

doi: 10.1186/s12891-021-04712-9

Figure Lengend Snippet: Rolipram restores ERK1/2 signaling to block TGF-β1 stimulated LF fibroblast fibrosis. (A) Different drugs were used to treat fibroblasts stimulated by TGF-β1. WB detects the expression of TGF-β1. a, Rolipram (50 nM) is a PDE4 inhibitor.; b, WAY-262611 (1 μM) is the Wnt/β-catenin pathway activator.; c, LY294002 (1 μM) is an inhibitor of the PI3K pathway; d, SCH772984 (1 μM) inhibits ERK1/2 signal transduction. (B) The expression of FN1 and TGF-β1 was up-regulated after exogenous TGF-β1 stimulation. Using Rolipram or SCH772984 blocked this change. (C) Western blot analysis reveals the expression levels of p-ERK1/2 and ERK1/2 in LF fibroblasts treated with TGF-β1 (5 ng/ mL) and Rolipram (50 nM, 24 h). β-tubulin served as an endogenous loading control. * p < 0.05

Article Snippet: Rolipram (CAS: 61413–54-5, CSNpharm, Shanghai, China), WAY-262611 (CAS: 1123231–07-1, CSNpharm), LY294002 (CAS: 154447–36-6, CSNpharm), SCH772984 (CAS: 942183–80-4, CSNpharm) were dissolved in DMSO.

Techniques: Blocking Assay, Expressing, Transduction, Western Blot, Control